Cartilage Tissue Engineering

What you'll learn
Cartilage structure
Cartilage damage
Cartilage tissue engineering
Cells in cartilage tissue engineering
Scaffolds in cartilage tissue engineering
Growth factors in cartilage tissue engineering
Requirements
System requirements: PC, laptop or mobile device (with Udemy app) and broadband connectivity.
Course requirements: There are no pre-requisite or other course requirements.
Description
Loss of cartilage regardless of the cause is problematic because of the extremely limited repair capacity of the tissue. Cartilage transplantation has never met success because of the scarcity of donor sites and the associated morbidity in the harvest procedures. It is known that the functional properties of cartilage are mainly dependent on its extracellular matrix (ECM) components. One common strategy involves the incorporation of different biomaterials, such as synthetic and natural polymers, to mimic the real ECM of this tissue. Niche signaling influences the mesenchymal stem cell (MSC) differentiation to chondrocytes. This microenvironment, or niche, could be established by a welldesigned polymeric scaffold together with the appropriate growth factor. Because cartilage is composed mainly of water, devices intended for its substitution or tissue regeneration should be made of a material that can hold large amounts of water and should also have good handling properties to withstand loads imparted by the cells and ECM during in vitro culturing.In recent years, different types of biocompatible biomaterials have used to repair cartilage damage by stem cells. Generally, cell activity is maintained inside a three‐dimensional scaffold. Synthetic hydrogels with suitable physical and...

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